To compare the limited USPSTF screening criteria to expanded criteria, the researchers conducted a cross-sectional study using data from a nationally representative sample of participants in the 2011 to 2014 National Health and Nutrition Examination Surveys study (NHANES). The study included 3643 adults who had never been diagnosed with diabetes. The study defined abnormal blood glucose as an HbA1c ≥5.7%, fasting blood glucose ≥100 mg/dL, and/or 2-hour blood glucose ≥140 mg/dL.
The researchers found that 49.7% of the study population had undiagnosed abnormal blood glucose. By ethnicity/race, the prevalence was 48.6% among non-Hispanic whites, 54.0% among blacks, 50.9% among Hispanic/Latinos, and 51.2% among Asians. Extrapolating from Census data, the researchers estimate that 105.1 million Americans have undiagnosed dysglycemia.
Lead author Matthew O’Brien, MD, Assistant Professor of Medicine at Northwestern University Feinberg School of Medicine, Chicago, Illinois (USA) said via email, “We believe that clinicians should use well-established risk factors to prompt screening for diabetes, rather than testing only middle-aged adults who are overweight or obese. Following such a narrow strategy will fail to screen some high-risk subgroups. This is especially a problem because some racial/ethnic groups develop diabetes at younger ages (i.e. those of Hispanic or African descent) or normal body weights (i.e. Asians) than Caucasians.”
Early screening for type 2 diabetes is important because it can enable earlier pharmacotherapy and lifestyle modification, potentially warding off serious complications of diabetes. The results also showed that using the limited criteria would miss other high-risk groups. These include women with polycystic ovarian syndrome and/or a history of gestational diabetes, and younger age groups who are increasingly at risk for diabetes.